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World TB Day 2019

World TB Day 2019

The South African Tuberculosis Vaccine Initiative (SATVI), is a world leader in TB vaccine clinical research located within the Health Sciences Faculty at the University of Cape Town.
“A world without TB”
The mission of SATVI  is the development of new and effective vaccination and other prevention strategies against tuberculosis (TB). A new, effective vaccine has the potential to save hundreds of thousands of lives world-wide. We are testing multiple new vaccine candidates in clinical trials. We are also completing projects to identify and validate biomarkers that can predict TB and are addressing critical clinical, epidemiological, immunological and human genetic questions in TB vaccine development. Our activities are within an academic context, and thus include the training of postgraduate students. The SATVI field site is located in the Boland region, 110km outside Cape Town, where the rate of TB is amongst the highest recorded in the world. This rural area of about 12,000 square kilometres has a population of about 350,000, of whom more than 20,000 have participated in our studies to date.

TB is a very serious disease that is caused by the bacterium, Mycobacterium tuberculosis. TB kills more people than any other single infectious organism and is the leading cause of death in people living with HIV and the main cause of deaths related to antimicrobial resistance.
Billions of people are infected with Mycobacterium tuberculosis, and the disease kills about 1.6 million of the 10 million people that develop the disease every year. TB can be treated with antibiotics, but finding, diagnosing and effectively treating all TB cases is extremely challenging. A highly effective TB vaccine would be the most effective strategy to get the global epidemic under control.

SATVI regards each of its >100 personnel members as critical for it’s success. Our team consists of specialists in: administration, clinical, epidemiological, human immunologic science, bioinformatics, clinical trials, community liaison, recruitment and follow-up; data management and analysis, disease surveillance, information technology, clinical evaluation and care of participants, facility management, laboratory technology, logistics, research pharmacy management, project management, regulatory affairs, study coordination and training.
We also have an active postgraduate academic training programme, with multiple postdoctoral fellows and PhD and Masters students.

SATVI Director, Professor Mark Hatherill, is supported by the Executive Committee comprising of Dr Masooda Kaskar (Chief Operations Officer), Professor Thomas Scriba (Deputy Director for Immunology and Laboratories) and Ms Marwou de Kock (Field Site Manager). We have two homes in the Faculty of Health Sciences; the Institute of Infectious Disease and Molecular Medicine (IDM) and in the Department of Pathology.  SATVI has offices and a state-of-the-art laboratory within the IDM in Cape Town. The latter includes a biobank which houses >500,000 human samples. The SATVI field site is located 110km outside Cape Town, where the rate of TB is amongst the highest recorded in the world. Here, >20,000 persons have participated in our studies to date. To date we have completed 28 clinical trials of new TB vaccines as well as other clinical and epidemiological studies. Our field site facilities include project offices, and a dedicated "Vaccine House", "Case Verification Ward", pharmacy and satellite immunology laboratory. These are located on the premises of Brewelskloof TB hospital, in Worcester.

SATVI was established in 2001 by Professor Gregory Hussey, who has now retired from the University of Cape Town. The late Professor Maurice Kibel worked closely with Professor Hussey in the early days, which focused on establishing critical clinical trials capacity, and addressing unanswered questions surrounding BCG.

What's happening on World TB Day 2019

Join the twitter discussion on 21 March 2019 at 15h00 (GMT)/11 (EDT). Click here.

Social Media section: What can you do?

Social Media. 

Facebook header: Replace your facebook header with the World TB Day header. Click here.

Facebook Profile picture. Click here to create a Twibbon.  Click here


Useful resources

Visit Stop Tb Partnership. Click here.

World Health Organisation. Click here.

TB situation in  South Africa/ Tb country profile. Click here.

Global End Strategy. Click here.