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Current and Completed General Studies

Protocol Title Principal Investigator Funder Publications
Helminth TB Helminth Study: The risk of pulmonaryTuberculosis associated with intestinal Helminth infection among children at two Tuberculosis Vaccine Trial Sites in Sub-Saharan African. Assoc Prof Mark Hatherill EDCTP  
A5300 (Phoenix) Study of multi-drug resistant (MDR) tuberculosis (TB) Cases and Their Household Contacts: Operational Feasibility to Inform Protecting household On Exposure to Newly diagnosed Index MDR TB cases (PHOENIx) Trial Design. Dr Justin Shenje ACTG  

Protocol
 

Title Principal Investigator Funder Publications
Rifaquin An International Multicentre Controlled Clinical Trial To Evaluate High Dose Rifapentine and A Quinolone In The Treatment Of Pulmonary Tuberculosis (RIFAQUIN)

CI: Jindani

PI: Assoc Prof Mark Hatherill

Sponsor:InterTB Funder: EDCTP  
Induced Sputum Diagnostic yield of induced sputum for rapid diagnosis of pulmonary tuberculosis (DMID 07-0058)

 

PI: Assoc Prof Mark Hatherill  Funder: NIH/NIAID/DMID  

DMID 07-0083

(Isoniazid (INH)

Phase I Study of Whether Preclearance of Latent M. tuberculosis (MTB) Infection With Isoniazid (INH) Enhances Specific Immune Responses to MTB Following Subsequent BCG Revaccination in Healthy, HIV-uninfected, Tuberculin Skin Test Positive Adults (DMID 07-0083)

 

PI: Assoc Prof Hatherill/Johnson

 

 

Sponsor: NIH/NIAID/DMID

Funder: NIH/NIAID/DMID via TBRU

 
  Drama sets the stage for clinical research in adolescents (Carina's Choice) Dr Michele Tameris Wellcome Trust  
  Impact of clinical research activities on the incident and spectrum of severe TB in young children.

Sizulu Moyo

Assoc Prof Mark Hatherill

   
6115A1-3002-WW

To evaluate the immune responses 1 month after 3 doses of 13vPnVcompared with the immune responses one month after 2 doses of 13 vPnC as measured by stereo-type specific immunoglobulin G (IgG) gemetric mean fold rises (GMFR) in subjects >6 years of age.

Dr Hennie Geldenhuys Pfizer  
SA/POL/001/2007 Comparative evaluation of immunogenicity of monovalent type 1 oral Poliovirus Vaccine (mOPV1) and monovalent type 3 oral poliovirus vacine (mOPV3) versus trivalent oral polio virus vaccine (tOPV): a randomised double-blind controlled trial in South Africa. Prof Greg Hussey World Health Organisation  
  Host-based assessment of Mycobacterium tuberculosis exposure (Buccal swab) Dr Angelique Luabeya University Washington  
  Impact of an audio-visual consenting tool on understanding of the informed consent process in a TB vaccine trial. Dr Michele Tameris UCT  
  Adolescent Trial Participation Narratives-A pilot study. Dr Hennie Geldenhuys MRC  
TB 027 An evaluation of the continued safety and immunogenicity of a new TB vaccine, MVA 85A, in healthy adults, adolescents, children and infants and asymptomatic TB and HIV infected adults who have received MVA 85A at least one year ago. Dr Michele Tameris Oxford  

HS 645

(Syringe Jet Injection Device)

A randomized clinical trial in adults and newborns in South Africa to compare the safety and immunogenicity of Bacille Calmette-Guérin (BCG) vaccine administration via a disposable-syringe jet injector to conventional technique with needle and syringe. Dr Hennie Geldenhuys

  PATH and World Health Organisation

 

Vaccine April 2015