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30 July 2017 Welcome to Professor David Lewinsohn

5 Aug 2017 - 13:45

On Wednesday 19 July 2017 Dr David Lewinsohn presented a seminar titled: "Human MR1 Restricted T Cells:  Sensors of the Microbial Metabolome" as part of the IDM seminars.

Dr David M. Lewinsohn is a Professor of Pulmonary and Critical Care Medicine at Oregon Health & Sciences University and holds adjunct appointments  in Molecular Microbiology & Immunology as well as the Vaccine and Gene Therapy Institute.  Dr. Lewinsohn received his undergraduate degree from Haverford College, his MD and PhD from Stanford University School of Medicine, internal medicine training at the University of California, San Francisco, and fellowship training in Pulmonary and Critical Care Medicine at the University of Washington.  
 
Dr. Lewinsohn’s research interest is in Tuberculosis Immunology.  The core research question has been that of how the immune system can find those cells harboring the intracellular bacterium.  As a result, he has been particularly interested in the role of CD8+ T cells in controlling infection, in the use of CD8+ T cells as a surrogate for bacterial burden, and in the development of an improved TB vaccine.  His contribution to the field has been to define novel types of Mycobacterium tuberculosis-specific CD8+ T cells that are restricted by the monomorphic (innate) HLA molecules such as HLA-E and MR1, and in the characterization of those antigens presented in the context of infection with Mtb.  Dr. Lewinsohn has had a longstanding interest in the immuno-diagnoses of infection with Mtb.  In this capacity, he has collaborated with the CDC, the TB Research Unit (TBRU), the Kwazulu-Natal Research Institute for HIV and TB, AERAS, Oxford University and UCSF.

While at SATVI, Dr. Lewinsohn will focus on the question as to whether or not MR1-restricted T cells have the capacity for immunologic memory.

On Wednesday 19 July 2017 he presented a seminar titled: " Human MR1 Restricted T Cells:  Sensors of the Microbial Metabolome" as part of the IDM seminars.