"Quite simply put, we are trying to ascertain why some of the babies, despite having been vaccinated at birth, still develop TB. We are part of the WAR AGAINST TB"
Ben Kagina, Research Officer
Research Publications
Since inception in 2000, SATVI has produced many high impact articles documenting research findings in international journals and made presentations at a range of international conferences. Below is a listing of research publications in order of most recently published:
Kalsdorf B, Skolimowska KH, Scriba TJ, Dawson R, Dheda K, Wood K, Hofmeister J, Hanekom WA, Lange C, Wilkinson RJ. In press, Eur J Immunol.
Day CL, Tameris M, Mansoor N, van Rooyen M, de Kock M, Geldenhuys H, Erasmus M, Makhethe L, Hughes EJ, Gelderbloem S, Bollaerts A, Bourguignon P, Cohen J, Demoitié MA, Mettens P, Moris P, Sadoff JC, Hawkridge A, Hussey GD, Mahomed H, Ofori-Anyinam O, Hanekom WA. Am J Respir Crit Care Med. 2013 Jan 10. [Epub ahead of print]
Longitudinal Changes in CD4+ T-Cell Memory Responses Induced by BCG Vaccination of Newborns.
Soares AP, Kwong Chung CK, Choice T, Hughes EJ, Jacobs G, van Rensburg EJ, Khomba G, de Kock M, Lerumo L, Makhethe L, Maneli MH, Pienaar B, Smit E, Tena-Coki NG, van Wyk L, Boom WH, Kaplan G, Scriba TJ, Hanekom WA. J Infect Dis. 2013 Jan 28. [Epub ahead of print]
Gonzalez-Angulo Y, Geldenhuys H, Van As D, Buckerfield N, Shea J, Mahomed H, Hanekom W, Hatherill M. Am J Infect Control. 2013 Jan 31. [Epub ahead of print]
Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, Shea JE, McClain JB, Hussey GD, Hanekom WA, Mahomed H, McShane H; the MVA85A 020 Trial Study Team. Lancet. 2013 Feb 1. [Epub ahead of print]
Varicella Zoster-Specific CD4+Foxp3+ T Cells Accumulate after Cutaneous Antigen Challenge in Humans.
Vukmanovic-Stejic M, Sandhu D, Sobande TO, Agius E, Lacy KE, Riddell N, Montez S, Dintwe OB, Scriba TJ, Breuer J, Nikolich-Zugich J, Ogg G, Rustin MH, Akbar AN. J Immunol. 2013 Feb
McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A. Immunogenetics. 2013 Feb 8. [Epub ahead of print]
Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.
Tameris M, McShane H, Lmcclain JB, Landry B, Lockhart S, Luabeya AK, Geldenhuys H, Shea J, Hussey G, van der Merwe L, de Kock M, Scriba T, Walker R, Hanekom W, Hatherill M, Mahomed H. Tuberculosis (Edinb). 2013 Feb 11. [Epub ahead of print]
Ritz N, Dutta B, Donath S, Casalaz D, Connell TG, Tebruegge M, Robins-Browne R, Hanekom WA, Britton WJ, Curtis N. Am J Respir Crit Care Med. 2012 Jan 15;185(2):213-22.
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.
Walker LJ, Kang YH, Smith MO, Tharmalingham H, Ramamurthy N, Fleming VM, Sahgal N, Leslie A, Oo Y, Geremia A, Scriba TJ, Hanekom WA, Lauer GM, Lantz O, Adams DH, Powrie F, Barnes E, Klenerman P. Blood. 2012 Jan 12;119(2):422-33.
Matthews K, Ntsekhe M, Syed F, Scriba T, Russell J, Tibazarwa K, Deffur A, Hanekom W, Mayosi BM, Wilkinson RJ, Wilkinson KA.Eur J Immunol. 2012 Jan;42(1):147-57. PMID: 22215422
Luabeya KK, Mulenga H, Moyo S, Tameris M, Sikhondze W, Geldenhuys H, Mohamed H, Hanekom W, Hussey G, Hatherill M. Pediatr Infect Dis J. 2012 Jan;31(1):42-6. PMID: 22094639.
A phase IIa Trial of the new TB Vaccine, MVA85A, in HIV and/or M. Tuberculosis Infected Adults.
Scriba TJ, Tameris M, Smit E, van der Merwe L, Hughes EJ, Kadira B, Mauff K, Moyo S, Brittain N, Lawrie A, Mulenga H, de Kock M, Makhethe L, van Rensburg EJ, Gelderbloem S, Veldsman A, Hatherill M, Geldenhuys H, Hill AV, Hawkridge A, Hussey GD, Hanekom WA, McShane H, Mahomed H. Am J Respir Crit Care Med. 2012 Jan 26.
Consensus Statement on Diagnostic End Points for Infant Tuberculosis Vaccine Trials.
Hatherill M, Verver S, Mahomed H; the Taskforce on Clinical Research Issues, Stop TB Partnership Working Group on TB Vaccines. Clin Infect Dis. 2011 Dec 5. [Epub ahead of print]
Shey MS, Hughes EJ, de Kock M, Barnard C, Stone L, Kollmann TR, Hanekom WA, Scriba TJ. J Immunol Methods. 2011 Dec 1. [Epub ahead of print]
Sputum induction for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis.
Gonzalez-Angulo Y, Wiysonge CS, Geldenhuys H, Hanekom W, Mahomed H, Hussey G, Hatherill M. Eur J Clin Microbiol Infect Dis. 2011 Nov 18. [Epub ahead of print]
Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine.
Zvada SP, Denti P, Geldenhuys H, Meredith S, van As D, Hatherill M, Hanekom W, Wiesner L, Simonsson US, Jindani A, Harrison T, McIlleron HM. Antimicrob Agents Chemother. 2012 Aug;56(8):4471-3.
Meeting report: The International Conference on Human Immunity to Tuberculosis.
Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J. Tuberculosis (Edinb). 2012;92(5):440-4.
SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis.
Hanekom WA, Hawkridge A, Mahomed H, Scriba TJ, Tameris M, Hughes J, Hatherill M, Day CL, Hussey GD. S Afr Med J. 2012;102(6):438-41.
Key issues in the clinical development and implementation of TB vaccines in South Africa.
Rustomjee R, Mcleod R, Hanekom W, Steel G, Mahomed H, Hawkridge A, Welte A, Sinanovic E, Loots G, Grobler A, Mvusi L, Gray G, Hesseling A, Ginsberg A, Lienhardt C, Shea J, Tong X, Lockhart S, Churchyard GJ. Tuberculosis (Edinb). 2012;92(5):359-64.
Detection and treatment of subclinical tuberculosis.
Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Thomas Dick, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SH, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young D. Tuberculosis (Edinb). 2012;92(6):447-52.
A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guérin immunisation in children and adults.
Ritz N, Strach M, Yau C, Dutta B, Tebruegge M, Connell TG, Hanekom WA, Britton WJ, Robins-Browne R, Curtis N. PLoS One. 2012;7(7):e37535.
Vaccine trials in the developing world: operational lessons learnt from a phase IV poliomyelitis vaccine trial in South Africa.
Geldenhuys H, Waggie Z, Jacks M, Geldenhuys M, Traut L, Tameris M, Hatherill M, Hanekom WA, Sutter R, Hussey G, Mahomed H. Vaccine. 2012;30(40):5839-43.
Predictive Value of Recent QuantiFERON Conversion for Tuberculosis Disease in Adolescents.
Machingaidze S, Verver S, Mulenga H, Abrahams DA, Hatherill M, Hanekom W, Hussey GD, Mahomed H. Am J Respir Crit Care Med. 2012;186(10):1051-6.
Genetic Variation in TLR Genes in Ugandan and South African Populations and Comparison with HapMap Data.
Baker AR, Qiu F, Randhawa AK, Horne DJ, Adams MD, Shey M, Barnholtz-Sloan J, Mayanja-Kizza H, Kaplan G, Hanekom WA, Boom WH, Hawn TR, Stein CM; Tuberculosis Research Unit (TBRU) and South African Tuberculosis Vaccine Initiative Team (SATVI). PLoS One. 2012;7(10):e47597.
Safety and tolerability of sputum induction in adolescents and adults with suspected pulmonary tuberculosis.
Geldenhuys HD, Kleynhans W, Buckerfield N, Tameris M, Gonzalez Y, Mahomed H, Hussey G, Hanekom W, Hatherill M. Eur J Clin Microbiol Infect Dis. 2012 Apr;31(4):529-37. doi: 10.1007/s10096-011-1344-5. Epub 2011 Jul 28.
Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.
Checkley AM, Wyllie DH, Scriba TJ, Golubchik T, Hill AV, Hanekom WA, McShane H. PLoS One. 2011;6(10):e26434. http://www.ncbi.nlm.nih.gov/pubmed/22046285
Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA. J Infect Dis. 2011 Nov 15;204(10):1550-6 http://www.ncbi.nlm.nih.gov/pubmed/21940422
Prospects for elimination of childhood tuberculosis: the role of new vaccines.
Hatherill M. Arch Dis Child. 2011 Sep;96(9):851-6. Epub 2011 Mar 30. Review. http://www.ncbi.nlm.nih.gov/pubmed/21450742
Prospects for a new, safer and more effective TB vaccine.
Hawkridge T, Mahomed H. Paediatr Respir Rev. 2011 Mar;12(1):46-51. Epub 2010 Oct 14. Review. http://www.ncbi.nlm.nih.gov/pubmed/21172675
Tuberculin skin test and QuantiFERON assay in young children investigated for tuberculosis in South Africa.
Moyo S, Isaacs F, Gelderbloem S, Verver S, Hawkridge AJ, Hatherill M, Tameris M, Geldenhuy H, Workman L, Pai M, Hussey G, Hanekom WA, Mahomed H. Int J Tuberc Lung Dis 2011. In Press.
Risky Behaviour and Psychosocial Correlates in Adolescents – is there a link with Tuberculosis?
Geldenhuys H, Sorsdahl K, Kafaar F, Hatherill M, Hanekom WA, Stein DJ, Mahomed H. Afric J Psychiatry 2011. In Press
Association of Human TLR1 & TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants.
Randhawa AK, Shey M, Keyser A, Peixoto B, Wells R, de Kock M, Lerumo L, Hughes J, Hussey G, Hawkridge A, Kaplan G, Hanekom W, Hawn T. Plos Pathog 2011. In press.
Functional Capacity of Mycobacterium tuberculosis-Specific T Cell Responses in Humans Is Associated with Mycobacterial Load
Cheryl L. Day, Deborah A. Abrahams, Lesedi Lerumo, Esme Janse van Rensburg, Lynnett Stone, Terrence O’rie, Bernadette Pienaar, Marwou de Kock, Gilla Kaplan, Hassan Mahomed, Keertan Dheda, and Willem A. Hanekom.J Immunol. 2011 In press. http://www.ncbi.nlm.nih.gov/pubmed/21775682
HIV specific gag responses in early infancy correlate with clinical outcome and inversely with viral load
Nqoko B, Day C, Mansoor N, de Kock M, Hughes EJ, Hawkdridge T, Kaplan G, Boom WH, Hussey GD, Hanekom WA. AIDS Res Hum Retroviruses. 2011 http://www.ncbi.nlm.nih.gov/pubmed/21476948
Dose-Finding Study of the Novel Tuberculosis Vaccine, MVA85A, in Healthy BCG-Vaccinated Infants.
Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Mauff K, Hughes EJ, Moyo S, Brittain N, Lawrie A, Mulenga H, de Kock M, Gelderbloem S, Veldsman A, Hatherill M, Geldenhuys H, Hill AV, Hussey GD, Mahomed H, Hanekom WA, McShane H. J Infect Dis. 2011;203(12):1832-43. http://www.ncbi.nlm.nih.gov/pubmed/21606542
Predictive factors for latent tuberculosis infection among adolescents in a high burden area in South Africa.
Hassan Mahomed, Tony Hawkridge, Suzanne Verver, Lawrence Geiter, Mark Hatherill, Deborah-Ann Abrahams, Rodney Ehrlich, Willem Albert Hanekom, Gregory Dudley Hussey on behalf of the SATVI adolescent study team. Int J Tuberc Lung Dis 2011 Mar;15(3):331-6. http://www.ncbi.nlm.nih.gov/pubmed/21333099
Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis.
Matthews K, Wilkinson KA, Kalsdorf B, Roberts T, Diacon A, Walzl G, Wolske J, Ntsekhe M, Syed F, Russell J, Mayosi BM, Dawson R, Dheda K, Wilkinson RJ, Hanekom WA and Scriba TJ. Journal of Tuberculosis 2011. (Epub ahead of print) http://www.ncbi.nlm.nih.gov/pubmed/21767990
Developing vaccinology expertise for Africa: six years and counting.
Wiysonge CS, Waggie Z, Mahomed H, Hawkridge A, Hatherill M, Hanekom W, Hussey GD. Vaccine 2011. Aug 11;29(35):5821-3. http://www.ncbi.nlm.nih.gov/pubmed/21718743
Safety and tolerability of sputum induction in adolescents and adults with suspected pulmonary tuberculosis.
Geldenhuys HD, Kleynhans W, Buckerfield N, Tameris M, Gonzalez Y, Mahomed H, Hussey G, Hanekom W, Hatherill M. Eur J Clin Microbiol Infect Dis. 2011 Jul 28. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/21796347
Phenotypic variability in childhood TB: Implications of diagnostic endpoints in tuberculosis vaccine trials.
Mulenga H, Moyo S, Workman L, Hawkridge T, Verver S, Tameris M, Geldenhuys H, Hanekom W, Mahomed H, Hussey G, Hatherill M. Journal of Vaccine 2011. Jun 10;29(26):4316-2 http://www.ncbi.nlm.nih.gov/pubmed/21527304
The tuberculin skin test versus Quantiferon TB Gold in predicting tuberculosis disease in an adolescent cohort study in South Africa.
Mahomed H, Hawkridge T, Verver S, Abrahams D, Geiter L, Hatherill M, Ehrlich R, Hanekom WA, Hussey GD. PLoS One. 2011 Mar 29;6(3):e17984. http://www.ncbi.nlm.nih.gov/pubmed/21479236
Immunological biomakers in Tuberculosis.
Walzl G, Ronacher K, Hanekom W, Scriba T, Zumla A. Nature Rev Immunol. 2011 April 08. May;11 (5) :343-54 http://www.ncbi.nlm.nih.gov/pubmed/21475309
The Utility of an Interferon Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection and Disease in Children: A Systematic Review and Meta-analysis.
Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y, Hatherill M, Moyo S, Hanekom W, Mahomed H. Pediatr Infect Dis J. 2011 Aug;30(8):694-700. http://www.ncbi.nlm.nih.gov/pubmed/21427627
Dominant TNF-α (+) Mycobacterium tuberculosis-specific CD4(+) T cell responses discriminate between latent infection and active disease.
Harari A, Rozot V, Enders FB, Perreau M, Stalder JM, Nicod LP, Cavassini M, Calandra T, Blanchet CL, Jaton K, Faouzi M, Day CL, Hanekom WA, Bart PA, Pantaleo G. Nat Med. 2011 Mar;17(3):372-6. http://www.ncbi.nlm.nih.gov/pubmed/21336285
Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa.
Mahomed H, Hawkridge T, Verver S, Geiter L, Hatherill M, Abrahams DA, Ehrlich R, Hanekom WA, Hussey GD; SATVI Adolescent Study Team. Int J Tuberc Lung Dis. 2011 Mar; 15(3):331-6. http://www.ncbi.nlm.nih.gov/pubmed/21333099
Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.
Semple PL, Watkins M, Davids V, Krensky AM, Hanekom WA, Kaplan G, Ress S. Clin Dev Immunol. 2011; 2011:438463. http://www.ncbi.nlm.nih.gov/pubmed/21234358
Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease.
Govender L, Abel B, Hughes EJ, Scriba TJ, Kagina BM, de Kock M, Walzl G, Black G, Rosenkrands I, Hussey GD, Mahomed H, Andersen P, Hanekom WA. Vaccine. 2010 Dec 10; 29(1):51-7. http://www.ncbi.nlm.nih.gov/pubmed/20974305
Specific T Cell Frequency and Cytokine Expression Profile do not correlate withprotection against tuberculosis, following BCG vaccination of newborns.
Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, Soares A, Gamieldien H, Sidibana M, Hatherill M, Gelderbloem S, Mahomed H, Hawkridge A, Hussey G, Kaplan G, Hanekom WA; other members of SATVI. Am J Respir Crit Care Med. 2010 (in press). http://www.ncbi.nlm.nih.gov/pubmed/20558627
The Tuberculin Skin Test: a comparison of reading with a ruler to reading with a calliper.
Hennie Geldenhuys, Suzanne Verver, Shireen Surtie, Mark Hatherill, Frank van Leth, Fazlin Kafaar, Michele Tameris, William Kleynhans, Kany Kany Luabeya, Sizulu Moyo, Welile Sikhondze, Willem Hanekom, Hassan Mahomed Int J Tuberc Lung Dis 2010. http://www.ncbi.nlm.nih.gov/pubmed/20843417
Age-related tuberculosis incidence and severity in children under 5 years of age in Cape Town, South Africa.
Moyo S, Verver S, Mahomed H, Hawkridge A, Kibel M, Hatherill M, Tameris M, Geldenhuys H, Hanekom W, Hussey G. Int J Tuberc Lung Dis. 2010 Feb;14(2):149-54. http://www.ncbi.nlm.nih.gov/pubmed/20074404
CD4 and CD8 T Cell Responses to Mycobacterial Antigens in African Children.
Tena-Coki NG, Scriba TJ, Peteni N, Eley B, Wilkinson RJ, Andersen P, Hanekom WA, Kampmann B.
Am J Respir Crit Care Med. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20224065
The Novel TB Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4 and CD8 T Cells in Adults.
Abel B, Tameris M, Mansoor N, Gelderbloem S, Hughes J, Abrahams D, Makhethe L, Erasmus M, de Kock M, van der Merwe L, Hawkridge A, Veldsman A, Hatherill M, Schirru G, Pau MG, Hendriks J, Weverling GJ, Goudsmit J, Sizemore D, McClain JB, Goetz M, Gearhart J, Mahomed H, Hussey GD, Sadoff JC, Hanekom WA. Am J Respir Crit Care Med. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20167847
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
Joosten SA, van Meijgaarden KE, van Weeren PC, Kazi F, Geluk A, Savage ND, Drijfhout JW, Flower DR, Hanekom WA, Klein MR, Ottenhoff TH. PLoS Pathog. 2010;6(2)http://www.ncbi.nlm.nih.gov/pubmed/20195504
Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.
Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Isaacs F, Keyser A, Moyo S, Brittain N, Lawrie A, Gelderbloem S, Veldsman A, Hatherill M, Hawkridge A, Hill AV, Hussey GD, Mahomed H, McShane H, Hanekom WA. Eur J Immunol. 2010;40(1)http://www.ncbi.nlm.nih.gov/pubmed/20017188
High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease.
Cobat A, Gallant CJ, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Beyers N, Jaïs JP, van Helden P, Abel L, Hoal EG, Alcaïs A, Schurr E. J Infect Dis. 2010;201(1):15-9. http://www.ncbi.nlm.nih.gov/pubmed/19938975
Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation.
Soares A, Govender L, Hughes J, Mavakla W, de Kock M, Barnard C, Pienaar B, Janse van Rensburg E, Jacobs G, Khomba G, Stone L, Abel B, Scriba TJ, Hanekom WA. J Immunol Methods. 2010 Oct 31; 362(1-2):43-50. http://www.ncbi.nlm.nih.gov/pubmed/20800066
Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence.
Gallant CJ, Cobat A, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Beyers N, Jaïs JP, van Helden P, Abel L, Alcaïs A, Hoal EG, Schurr E. Int J Tuberc Lung Dis. 2010 Aug;14(8):952-9. http://www.ncbi.nlm.nih.gov/pubmed/20626938
Tuberculosis research update.
Hanekom WA, Lawn SD, Dheda K, Whitelaw A. Trop Med Int Health. 2010 Aug; 15(8):981-9. http://www.ncbi.nlm.nih.gov/pubmed/20561306
Novel vaccine prime and selective BCG boost: a new tuberculosis vaccine strategy for infants of HIV-infected mothers.
Hatherill M, Mahomed H, Hanekom W. Vaccine. 2010 Jun 23; 28(29):4550-2. http://www.ncbi.nlm.nih.gov/pubmed/20470797
Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion.
Shey MS, Randhawa AK, Bowmaker M, Smith E, Scriba TJ, de Kock M, Mahomed H, Hussey G, Hawn TR, Hanekom WA. Genes Immun. 2010 Oct; 11(7):561-72. http://www.ncbi.nlm.nih.gov/pubmed/20445564
Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women.
Bere A, Denny L, Hanekom W, Burgers WA, Passmore JA. J Immunol Methods. 2010 Mar 31; 354(1-2):68-79. http://www.ncbi.nlm.nih.gov/pubmed/20149794
Tuberculin skin test and in-vitro assays provide complementary measures of anti-mycobacterial immunity in children and adolescents.
Gallant CJ, Cobat A, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Beyers N, Jaïs JP, van Helden P, Abel L, Alcaïs A, Hoal EG, Schurr E. Chest. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20040612
Hatherill M, Hanslo M, Hawkridge T, Little F, Workman L, Mahomed H, Michele Tameris, Sizulu Moyo, Hennie Geldenhuys, Willem Hanekom, Lawrence Geiter, Gregory Hussey. Bull World Health Organ 2009;88:312-320. http://www.who.int/bulletin/volumes/88/4/09-062893.pdf
Comparison of Mantoux and Tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis.
Pan W, Matizirofa L, Workman L, Hawkridge T, Hanekom W, Mahomed H, Hussey G, Hatherill M.
PLoS ONE 2009;4:e8085. Doi:10.1371/journal.pone.0008085. http://www.ncbi.nlm.nih.gov/pubmed/19956612
New vaccines against tuberculosis.
Lambert PH, Hawkridge T, Hanekom WA. Clin Chest Med. 2009;30(4):811-26. http://www.ncbi.nlm.nih.gov/pubmed/19925969
Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis.
Cobat A, Gallant CJ, Simkin L, Black GF, Stanley K, Hughes J, Doherty TM, Hanekom WA, Eley B, Jaïs JP, Boland-Auge A, van Helden P, Casanova JL, Abel L, Hoal EG, Schurr E, Alcaïs A. J Exp Med. 2009;206(12):2583-9. http://www.ncbi.nlm.nih.gov/pubmed/19901083
HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria.
Kalsdorf B, Scriba TJ, Wood K, Day CL, Dheda K, Dawson R, Hanekom WA, Lange C, Wilkinson RJ.
Am J Respir Crit Care Med. 2009;180(12):1262-70. http://www.ncbi.nlm.nih.gov/pubmed/19797156
Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract.
Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, Allan B, Williamson AL, Coetzee D, Olivier AJ, Burgers WA, Passmore JA. Immunology. 2009 Sep; 128(1 Suppl):e746-57. http://www.ncbi.nlm.nih.gov/pubmed/19740336
Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis.
Wilkinson KA, Seldon R, Meintjes G, Rangaka MX, Hanekom WA, Maartens G, Wilkinson RJ.
Am J Respir Crit Care Med. 2009;180(7):674-83. http://www.ncbi.nlm.nih.gov/pubmed/19628776
Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response.
Kagina BM, Abel B, Bowmaker M, Scriba TJ, Gelderbloem S, Smit E, Erasmus M, Nene N, Walzl G, Black G, Hussey GD, Hesseling AC, Hanekom WA. Vaccine. 2009;27(40):5488-95. http://www.ncbi.nlm.nih.gov/pubmed/19616494
Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa.
Black GF, Thiel BA, Ota MO, Parida SK, Adegbola R, Boom WH, Dockrell HM, Franken KL, Friggen AH, Hill PC, Klein MR, Lalor MK, Mayanja H, Schoolnik G, Stanley K, Weldingh K, Kaufmann SH, Walzl G, Ottenhoff TH; GCGH Biomarkers for TB Consortium. Clin Vaccine Immunol. 2009 Aug; 16(8):1203-12. http://www.ncbi.nlm.nih.gov/pubmed/19553548
The potential impact of helminth infection on trials of novel tuberculosis vaccines.
Hatherill M, Adams V, Hughes J, De Kock M, Mavakla W, Pienaar B, Mahomed H, Hussey G, Hanekom WA. Vaccine. 2009;27(35):4743-4. http://www.ncbi.nlm.nih.gov/pubmed/19450634
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth.
Fletcher HA, Keyser A, Bowmaker M, Sayles PC, Kaplan G, Hussey G, Hill AV, Hanekom WA.
BMC Med Genomics. 2009;2:10. 14.http://www.ncbi.nlm.nih.gov/pubmed/19239680
HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine.
Mansoor N, Scriba TJ, de Kock M, Tameris M, Abel B, Keyser A, Little F, Soares A, Gelderbloem S, Mlenjeni S, Denation L, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA.
J Infect Dis. 2009;199(7):982-90. 15. http://www.ncbi.nlm.nih.gov/pubmed/19236280
Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting.
Nicol MP, Davies MA, Wood K, Hatherill M, Workman L, Hawkridge A, Eley B, Wilkinson KA, Wilkinson RJ, Hanekom WA, Beatty D, Hussey G. Pediatrics. 2009;123(1):38-43. http://www.ncbi.nlm.nih.gov/pubmed/19117858
Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
Mansoor N, Abel B, Scriba TJ, Hughes J, de Kock M, Tameris M, Mlenjeni S, Denation L, Little F, Gelderbloem S, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA.
Clin Immunol. 2009;130(3):280-9. http://www.ncbi.nlm.nih.gov/pubmed/18996749
Induced sputum or gastric lavage for community-based diagnosis of childhood pulmonary tuberculosis?
Hatherill M, Hawkridge T, Zar HJ, Whitelaw A, Tameris M, Workman L, Geiter L, Hanekom WA, Hussey G. Arch Dis Child. 2009;94(3):195-201. http://www.ncbi.nlm.nih.gov/pubmed/18829621
Vaccines for Africa (VACFA) website – an innovative immunization advocacy tool.
Wiysonge CS, Waggie Z, Rhoda L, Hussey G. S Afr Med J 2009;99:275. http://www.ncbi.nlm.nih.gov/pubmed/19588779
Improving communication for immunisation in Africa: contribution of the Vaccines for Africa website.
Wiysonge CS, Waggie Z, Rhoda L, Hussey G. Pan African Medical Journal 2009;2:3. http://www.panafrican-med-journal.com/content/editorial/2/3/
Lessons and myths in the HIV/AIDS response.
Wiysonge CS, Muula AS, Kongnyuy EJ, Shey MS, Hussey GD. Lancet 2009;374:1675. http://www.ncbi.nlm.nih.gov/pubmed/19914511
Assessment of childhood immunisation coverage.
Wiysonge CS, Ofal J. Lancet 2009;373:1427-28. http://www.ncbi.nlm.nih.gov/pubmed/19394533
Make the money work for health in sub-Saharan Africa.
Wiysonge CS, Lavis JN, Volmink J. Lancet 2009;373:1174. http://www.ncbi.nlm.nih.gov/pubmed/19345830
A combination drug of abacavir-lamivudine-zidovudine (Trizivir®) for treating HIV infection and AIDS.
Shey M, Kongnyuy EJ, Shang J, Wiysonge CS. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD005481. DOI: 10.1002/14651858.CD005481.pub2. http://www.ncbi.nlm.nih.gov/pubmed/19588374
Interventions to reduce haemorrhage during myomectomy for fibroids.
Kongnyuy EJ, Wiysonge CS. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD005355. DOI: 10.1002/14651858.CD005355.pub3. http://www.ncbi.nlm.nih.gov/pubmed/19588371
Midwife-led versus other models of care for childbearing women: RHL commentary (last revised: 1 September 2009).
Wiysonge CS. The WHO Reproductive Health Library; Geneva: World Health Organization. http://apps.who.int/rhl/pregnancy_childbirth/antenatal_care/general/cd004667_Wiysongecs_com/en/index.html
Hawkridge A, Hatherill M, Little F, Goetz MA, Barker L, Mahomed H, Sadoff J, Hanekom W, Geiter L, Hussey G; South African BCG trial team. BMJ. 2008 Nov 13;337:a2052. doi: 10.1136/bmj.a2052.
http://www.ncbi.nlm.nih.gov/pubmed/19008268
Evaluation of the quality of informed consent in a vaccine field trial in a developing country setting.
Minnies D, Hawkridge T, Hanekom W, Ehrlich R, London L, Hussey G. BMC Med Ethics. 2008 Sep 30; 9:15. http://www.ncbi.nlm.nih.gov/pubmed/18826637
CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.
Sharma TS, Hughes J, Murillo A, Riley J, Soares A, Little F, Mitchell CD, Hanekom WA.
PLoS One. 2008;3(12):e3986. http://www.ncbi.nlm.nih.gov/pubmed/19096522
Exposure of cord blood to Mycobacterium bovis BCG induces an innate response but not a T-cell cytokine response.
Watkins ML, Semple PL, Abel B, Hanekom WA, Kaplan G, Ress SR. Clin Vaccine Immunol. 2008;15(11):1666-73. http://www.ncbi.nlm.nih.gov/pubmed/18815231
A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers.
Hoft DF, Blazevic A, Abate G, Hanekom WA, Kaplan G, Soler JH, Weichold F, Geiter L, Sadoff JC, Horwitz MA. J Infect Dis. 2008;198(10):1491-501. http://www.ncbi.nlm.nih.gov/pubmed/18808333
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.
Beveridge NE, Fletcher HA, Hughes J, Pathan AA, Scriba TJ, Minassian A, Sander CR, Whelan KT, Dockrell HM, Hill AV, Hanekom WA, McShane H. Tuberculosis (Edinb). 2008;88(6):631-40. http://www.ncbi.nlm.nih.gov/pubmed/18801705
Are adolescents ready for tuberculosis vaccine trials?
Mahomed H, Shea J, Kafaar F, Hawkridge T, Hanekom WA, Hussey GD. Vaccine. 2008;26(36):4725-30. http://www.ncbi.nlm.nih.gov/pubmed/18620015
Influence of BCG vaccine strain on the immune response and protection against tuberculosis.
Ritz N, Hanekom WA, Robins-Browne R, Britton WJ, Curtis N. FEMS Microbiol Rev. 2008;32(5):821-41. http://www.ncbi.nlm.nih.gov/pubmed/18616602
Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations.
Hanekom WA, Dockrell HM, Ottenhoff TH, Doherty TM, Fletcher H, McShane H, Weichold FF, Hoft DF, Parida SK, Fruth UJ. PLoS Med. 2008;5(7):e145. http://www.ncbi.nlm.nih.gov/pubmed/18597551
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa.
Hawkridge T, Scriba TJ, Gelderbloem S, Smit E, Tameris M, Moyo S, Lang T, Veldsman A, Hatherill M, Merwe L, Fletcher HA, Mahomed H, Hill AV, Hanekom WA, Hussey GD, McShane H.
J Infect Dis. 2008;198(4):544-52. http://www.ncbi.nlm.nih.gov/pubmed/18582195
Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles.
Soares AP, Scriba TJ, Joseph S, Harbacheuski R, Murray RA, Gelderbloem SJ, Hawkridge A, Hussey GD, Maecker H, Kaplan G, Hanekom WA. J Immunol. 2008;180(5):3569-77. http://www.ncbi.nlm.nih.gov/pubmed/18292584
Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.
Scriba TJ, Kalsdorf B, Abrahams DA, Isaacs F, Hofmeister J, Black G, Hassan HY, Wilkinson RJ, Walzl G, Gelderbloem SJ, Mahomed H, Hussey GD, Hanekom WA. J Immunol. 2008;180(3):1962-70. .http://www.ncbi.nlm.nih.gov/pubmed/18209095
Hanekom WA, Abel B, Scriba TJ. S Afr Med J. 2007;97(10 Pt 2):973-7. http://www.ncbi.nlm.nih.gov/pubmed/18000583
Immunology of infants through adolescents: responses to emulate for HIV vaccines.
Jaspan HB, Hanekom WA. Curr Opin HIV AIDS. 2007;2(5):391-8. http://www.ncbi.nlm.nih.gov/pubmed/19372917
Childhood tuberculosis: old and new vaccines.
Hussey G, Hawkridge T, Hanekom W. Paediatr Respir Rev. 2007 Jun; 8(2):148-54. Review. http://www.ncbi.nlm.nih.gov/pubmed/17574159
Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates.
Davids V, Hanekom W, Gelderbloem SJ, Hawkridge A, Hussey G, Sheperd R, Workman L, Soler J, Murray RA, Ress SR, Kaplan G. Clin Vaccine Immunol. 2007 Feb; 14(2):198-200. http://www.ncbi.nlm.nih.gov/pubmed/17182761
Determining causes of mortality in children enrolled in a vaccine field trial in a rural area in the Western Cape Province of South Africa.
Moyo S, Hawkridge T, Mahomed H, Workman L, Minnies D, Geiter LJ, Verver S, Kibel M, Hussey GD.
J Paediatr Child Health. 2007;43(3):178-83. http://www.ncbi.nlm.nih.gov/pubmed/17316193
Hatherill M, Hawkridge T, Whitelaw A, Tameris M, Mahomed H, Moyo S, Hanekom W, Hussey G. PLoS One. 2006 Dec 20; 1:e21. http://www.ncbi.nlm.nih.gov/pubmed/17183648
The impact of a change in bacille Calmette-Guérin vaccine policy on tuberculosis incidence in children in Cape Town, South Africa.
Mahomed H, Kibel M, Hawkridge T, Schaaf HS, Hanekom WA, Iloni K, Michaels D, Workman L, Verver S, Geiter L, Hussey GD. Pediatr Infect Dis J. 2006;25(12):1167-72. http://www.ncbi.nlm.nih.gov/pubmed/17133164
Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response.
Murray RA, Mansoor N, Harbacheuski R, Soler J, Davids V, Soares A, Hawkridge A, Hussey GD, Maecker H, Kaplan G, Hanekom WA. J Immunol. 2006;177(8):5647-51. http://www.ncbi.nlm.nih.gov/pubmed/17015753
Quantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosis.
Mendelson M, Hanekom WA, Ntutela S, Vogt M, Steyn L, Maartens G, Kaplan G. Clin Vaccine Immunol. 2006;13(12):1299-306. http://www.ncbi.nlm.nih.gov/pubmed/17005928
Comparison of mantoux skin test with three generations of a whole blood IFN-gamma assay for tuberculosis infection.
Mahomed H, Hughes EJ, Hawkridge T, Minnies D, Simon E, Little F, Hanekom WA, Geiter L, Hussey GD. Int J Tuberc Lung Dis. 2006 Mar;10(3):310-6. Erratum in: Int J Tuberc Lung Dis. 2006;10(6):708. http://www.ncbi.nlm.nih.gov/pubmed/16562712
The effect of bacille Calmette-Guérin vaccine strain and route of administration on induced immune responses in vaccinated infants.
Davids V, Hanekom WA, Mansoor N, Gamieldien H, Gelderbloem SJ, Hawkridge A, Hussey GD, Hughes EJ, Soler J, Murray RA, Ress SR, Kaplan G. J Infect Dis. 2006;193(4):531-6. http://www.ncbi.nlm.nih.gov/pubmed/16425132
Hanekom WA. Ann N Y Acad Sci. 2005;1062:69-78. http://www.ncbi.nlm.nih.gov/pubmed/16461790
Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study.
Zar HJ, Hanslo D, Apolles P, Swingler G, Hussey G.
Lancet 2005 Jun 4-10;365(9475):1926. http://www.ncbi.nlm.nih.gov/pubmed/15639294
Hanekom WA, Hughes J, Mavinkurve M, Mendillo M, Watkins M, Gamieldien H, Gelderbloem SJ, Sidibana M, Mansoor N, Davids V, Murray RA, Hawkridge A, Haslett PA, Ress S, Hussey GD, Kaplan G.
J Immunol Methods. 2004;291(1-2):185-95. http://www.ncbi.nlm.nih.gov/pubmed/15345316
Nicol M, Eley B, Kibel M, Hussey G.
S Afr Med J 2002 Jan;92(1):39-42. http://www.ncbi.nlm.nih.gov/pubmed/11936013
Zar HJ, Tannenbaum E, Apolles P, Roux P, Hanslo D, Hussey G.
Arch Dis Child. 2000 Apr;82(4):305-8. http://www.ncbi.nlm.nih.gov/pubmed/10735837
